• Home
• News
  • Faustman Lab News
  • Lab Newsletter
  • Media Coverage
  • Academic Publications
  • Sign up for e-mail updates
• Support
  • Support the Faustman Lab
  • Make a gift
  • Host a fundraiser or event
  • Get our fundraising brochure
• Research
  • Research Overview
  • Immunology Research at Mass General
  • Academic Publications
  • Research FAQ
• Clinical Trials
  • Clinical Trials Info
  • Clinical Trials FAQ
  • Clinical Trials Contact
  • Patient Information Sheet
• Contact

Dr. Denise Faustman

Support the search for a cure
The research conducted by the Faustman Lab depends on the support of people like you.
>Make a gift today!

Academic Publications

Selected Faustman Lab publications, including PDFs of journal articles and links to abstracts, are included here.

• MORAWIETZ L, MARTINEZ-GAMBOA L, SCHEFFLER S, HAUSDORF G, DANKOF A,
  KUCKELKORN U, DOERNER T, EGERER K, GERD-R. BURMESTER, DENISE L. FAUSTMAN DL and FEIST E. Expression of Proteasomal Immunosubunit ß1i Is
  Dysregulated in Inflammatory Infiltrates of Minor Salivary Glands in Sjögren’s Syndrome. The Journal of Rheumatology. Full Paper
• Dieguez-Acuna F, Kodamab S, Okubob Y, Pazc AC, Gygia ST and Faustmanb DL. Proteomics identifies multipotent and low oncogenic risk stem cells of the spleen. The International Journal of Biochemistry & Cell Biology. Full Paper
• Faustman DL and Davis M. The primacy of CD8 T lymphocytes in type 1 diabetes and implications for therapies. J Mol Med. Published online 21 August 2009. Full Paper
• Liqin B, Zhang J, Wang L, Kuhtreiber W, Burger D, and Faustman DL. Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism. Proceedings of the National Academy of Sciences; 13,644-13,649. Full Paper
• Liston A. Autoimmunity: Beyond the immune system. Immunol Cell Biol 2008; 1-2. Full Paper
• Lonyai A, Kodama S, Burger D, Faustman DL. Fetal Hox11 expression patterns predict defective target organs: a novel link between developmental biology and autoimmunity. Immunol Cell Biol 2008; 1-9. Full Paper
• Lonyai A, Kodama S, Burger D, Davis M, Faustman DL. The promise of Hox11+ stem cells of the spleen for treating autoimmune diseases. Horm Metab Res 2008; 40:137-46. Full Paper
• Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Khalili S, Faustman DL, Mezey E. Reversal of Sjogren's-like syndrome in non-obese diabetic mice. Ann Rheum Dis 2007; 66:812-4. Full Paper
• Dieguez-Acuna FJ, Gygi SP, Davis M, Faustman DL. Splenectomy: a new treatment option for ALL tumors expressing Hox-11 and a means to test the stem cell hypothesis of cancer in humans. Leukemia 2007; 21;2192-235. Full Paper
• Faustman DL. Reversal of type 1 diabetes in mice. N Engl J Med 2007; 356:311-2. Full Paper
• Faustman DL. Permanent reversal of diabetes in NOD mice. Science 2007; 317:196. Full Paper
• Dale E, Davis M, Faustman DL. A role for transcription factor NF-kB in autoimmunity: possible interactions of genes, sex, and the immune response. Adv Physiol Edu 2006; 30:152-8. Full Paper
• Kodama S, Davis M, Faustman DL. Regenerative medicine: a radical reappraisal of the spleen. Trends Molec Med 2005; 11:271-6. Full Paper
• Kodama S, Davis M, Faustman DL. Diabetes and Stem Cell Researchers Turn to the Lowly Spleen. Sci Aging Knowl. Environ. 2005; pe2. Full Paper
• Dieguez-Acuna FJ, Gerber SA, Kodama S, Elias JE, Beausoleil SA, Faustman D, Gygi SP. Characterization of mouse spleen cells by subtractive proteomics. Molec Cell Proteomics 2005: 4:1459-70. Full Paper
• Kuhtreiber WM, Kodama S, Burger DE, Dale EA, Faustman DL. Methods to characterize lymphoid apoptosis in a murine model of autoreactivity. J Immunol Meth 2005; 306:137-50. Full Paper
• Kodama S, Davis M, Faustman DL. The therapeutic potential of tumor necrosis factor for autoimmune disease: a mechanistically based hypothesis. Cell Molec Life Sci 2005; 62: 1850-62. Full Paper
• Kodama S, Faustman DL. Routes to regenerating islet cells: stem cells and other biological therapies for type 1 diabetes. Pediatric Diabetes 2004; 5:38-44. Full Paper
• Kuhtreiber WM, Kodama S, Burger DE, Dale EA, Faustman DL. Methods to characterize lymphoid apoptosis in a murine model of autoreactivity. J Immunol Methods. 2005 Nov 30;306(1-2):137-50. Abstract
• Dieguez-Acuna FJ, Gerber SA, Kodama S, Elias JE, Beausoleil SA, Faustman D, Gygi SP. Characterization of mouse spleen cells by subtractive proteomics. Mol Cell Proteomics. 2005 Oct;4(10):1459-1470. Abstract
• Kodama S, Davis M, Faustman DL. The therapeutic potential of tumor necrosis factor for autoimmune disease: a mechanistically based hypothesis. Cell Mol Life Sci. 2005 Aug;62(16):1850-62. Abstract
• Kodama S, Davis M, Faustman DL. Regenerative medicine: a radical reappraisal of the spleen. Trends Mol Med. 2005 Jun;11(6):271-6. Abstract
• Kodama S, Davis M, Faustman DL. Diabetes and stem cell researchers turn to the lowly spleen. Sci Aging Knowledge Environ. 2005 Jan 19;2005(3):pe2. Abstract
• Kodama S, Faustman DL. Routes to regenerating islet cells: stem cells and other biological therapies for type 1 diabetes. Pediatr Diabetes. 2004;5 Suppl 2:38-44. Abstract
• Abraham EJ, Kodama S, Lin JC, Ubeda M, Faustman DL, Habener JF. Human pancreatic islet-derived progenitor cell engraftment in immunocompetent mice. Am J Pathol. 2004 Mar;164(3):817-30. Abstract
• Kuhtreiber WM, Hayashi T, Dale EA, Faustman DL. Central role of defective apoptosis in autoimmunity. J Mol Endocrinol. 2003 Dec;31(3):373-99. Abstract
• Hayashi T, Faustman DL. Role of defective apoptosis in type 1 diabetes and other autoimmune diseases. Recent Prog Horm Res. 2003;58:131-53. Abstract
• Penfornis A, Yan G, Shi L, Faustman DL. Polymorphisms of human TAP2 detected by denaturing gradient gel electrophoresis. Hum Immunol. 2003 Jan;64(1):156-67. Abstract
• Yan G, Shi L, Penfornis A, Faustman DL. Impaired processing and presentation by MHC class II proteins in human diabetic cells. J Immunol. 2003;170:620-7. Abstract
• Kodama S, Kuhtreiber W, Fujimura S, Dale EA, Faustman DL. Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science. 2003;302:1223-7. Abstract
• Hayashi T, Faustman DL. Development of spontaneous uterine tumors in low molecular mass polypeptide-2 knockout mice. Cancer Res. 2002 Jan 1;62(1):24-7. Abstract
• Hayashi T, Faustman DL. Selected contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis. J Appl Physiol. 2001 Dec;91(6):2804-15. Abstract
• Ryu S, Kodama S, Ryu K, Schoenfeld DA, Faustman DL. Reversal of established autoimmune diabetes by restoration of endogenous ß-cell function. J Clin Invest. 2001; 108:63-72. Abstract
• Hayashi T, Faustman DL. Implications of altered apoptosis in diabetes mellitus and autoimmune disease. Apoptosis. 2001 Feb-Apr;6(1-2):31-45. Abstract
• Hayashi T, Faustman D. Essential role of human leukocyte antigen-encoded proteasome subunits in NF-kappaB activation and prevention of tumor necrosis factor-alpha-induced apoptosis. J Biol Chem. 2000 Feb 18; 275(7):5238-47. Abstract
• Hayashi T, Kodama S, Faustman D. Reply to 'LMP2 expression proteasome activity in NOD mice. Nature Med. 2000; 6:1065-66. Abstract
• Hayashi T, Faustman D. Defective function of the proteasome in autoimmunity: involvement of impaired NF-kappaB activation. Diabetes Technol Ther. 2000 Autumn;2(3):415-28. Abstract
• Hayashi T, Faustman D. NOD mice are defective in proteasome production and activation of NF-kappaB. Mol Cell Biol. 1999 Dec; 19(12):8646-59. Abstract
• Yan G, Shi L, Fu Y, Wang X, Schoenfeld D, Ma L, Penfornis A, Gebel H, Faustman DL. Screening of the TAP1 gene by denaturing gradient gel electrophoresis in insulin-dependent diabetes mellitus: detection and comparison of new polymorphisms between patients and controls. Tissue Antigens. 1997 Dec;50(6):576-85. Abstract
• Faustman DL. Gender is important: lessons in autoimmunity. J Womens Health. 1997 Oct;6(5):521-2. Abstract
• Yan G, Fu Y, Faustman DL. Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter. J Immunol. 1997 Sep 15;159(6):3068-80. Abstract
• Huang R, Guo J, Li X, Faustman DL. Elimination of self-peptide major histocompatibility complex class I reactivity in NOD and beta 2-microglobulin-negative mice. Diabetes. 1995 Sep;44(9):1114-20. Abstract
• Li F, Linan MJ, Stein MC, Faustman DL. Reduced expression of peptide-loaded HLA class I molecules on multiple sclerosis lymphocytes. Ann Neurol. 1995 Aug;38(2):147-54. Abstract
• Wang F, Li X, Annis B, Faustman DL. Tap-1 and Tap-2 gene therapy selectively restores conformationally dependent HLA Class I expression in type I diabetic cells. Hum Gene Ther. 1995 Aug;6(8):1005-17. Abstract
• Faustman DL. Altered MHC class I expression: a role for transplantation and IDDM autoimmunity. Diabetes Metab Rev. 1995 Apr;11(1):1-19. Abstract
• Vidal-Puig A, Faustman DL. Tolerance to peripheral tissue is transient and maintained by tissue-specific class I expression. Transplant Proc. 1994 Dec;26(6):3314-6. Abstract
• Li F, Guo J, Fu Y, Yan G, Faustman D. Abnormal class I assembly and peptide presentation in the nonobese diabetic mouse. Proc Natl Acad Sci USA. 1994;91:11128-32. Abstract
• Faustman DL. Occult CD45 T cell developmental defect in type 1 diabetes. Diabete Metab. 1993 Sep-Oct;19(5):446-57. Abstract
• Li X, Golden J, Faustman DL. Faulty major histocompatibility complex class II I-E expression is associated with autoimmunity in diverse strains of mice. Autoantibodies, insulitis, and sialadenitis. Diabetes. 1993 Aug;42(8):1166-72. Abstract
• Fu Y, Nathan DM, Li F, Li X, Faustman DL. Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity. J Clin Invest. 1993;91:2301-7. Abstract
• Faustman DL. MHC class I and autoimmune diabetes. Biomed Pharmacother. 1993;47(1):3-10. Abstract
• Lanza RP, Butler DH, Borland KM, Harvey JM, Faustman DL, Solomon BA, Muller TE, Rupp RG, Maki T, Monaco AP, et al. Successful xenotransplantation of a diffusion-based biohybrid artificial pancreas: a study using canine, bovine, and porcine islets. Transplant Proc. 1992 Apr;24(2):669-71. Abstract
• Faustman D, Coe C. Prevention of xenograft rejection by masking donor HLA class I antigens. Science. 1991 Jun;252(5013):1700-2. Abstract
• Faustman D, Li XP, Lin HY, Fu YE, Eisenbarth G, Avruch J, Guo J. Linkage of faulty major histocompatibility complex class I to autoimmune diabetes. Science. 1991 Dec 20;254(5039):1756-61. Abstract
• Lanza RP, Butler DH, Borland KM, Staruk JE, Faustman DL, Solomon BA, Muller TE, Rupp RG, Maki T, Monaco AP, et al. Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11100-4. Abstract
• Breitmeyer JB, Faustman DL. Sheep erythrocyte rosetting induces multiple alterations in T lymphocyte function: inhibition of T cell receptor activity and stimulation of T11/CD2. Cell Immunol. 1989 Oct 1;123(1):118-33. Abstract
• Faustman DL, Hauptfeld V, Davie JM, Lacy PE. Prolonged survival of donor skin grafts on mice bearing established islet of Langerhans transplants. Transplantation. 1985 Aug;40(2):216-8. Abstract
• Faustman DL, Steinman RM, Gebel HM, Hauptfeld V, Davie JM, Lacy PE. Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody. Proc Natl Acad Sci U S A. 1984 Jun;81(12):3864-8. Abstract

© 2008 Massachusetts General Hospital